Haematology: Treating patients with blood disorders in ICU

Management of sickle cell anaemia in ITU:

1. Recognise the unique challenges and complications of managing sickle cell anaemia patients in the intensive care setting.
2. Understand the importance of early intervention and multidisciplinary care in improving patient outcomes.
3. Identify key strategies for managing acute chest syndrome, vaso-occlusive crises, and other sickle cell-related complications in the ITU.

Management of red cell transfusions on ICU:

1. Understand the indications and risks associated with red cell transfusions in critically ill patients.
2. Learn about evidence-based transfusion thresholds and strategies for minimizing transfusion-related complications.
3. Discuss the role of alternative therapies, such as erythropoiesis-stimulating agents, in reducing the need for red cell transfusions on the ICU.

Management of platelet transfusions in ICU:

1. Recognise the indications and contraindications for platelet transfusions in critically ill patients.
2. Understand the importance of platelet count monitoring and the use of platelet function tests in guiding transfusion decisions.
3. Discuss strategies for preventing and managing platelet refractoriness and other transfusion-related complications.

Management of cytokine release syndrome and ICANs in patients admitted to critical care:

1. Understand the pathophysiology and clinical presentation of cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome (ICANs) in critically ill patients.
2. Learn about the grading systems and diagnostic criteria for these conditions.
3. Discuss the latest evidence-based management strategies, including the use of tocilizumab and corticosteroids, for treating cytokine release syndrome and ICANs in the critical care setting.

Immunothrombosis and models of haemostasis and thrombosis:

1. Understand the concept of immunothrombosis and its role in the pathogenesis of thrombotic disorders in critically ill patients.
2. Learn about the latest research on the interplay between the immune system and the coagulation cascade.
3. Discuss the implications of immunothrombosis for the development of novel diagnostic and therapeutic strategies in the management of thrombosis on the ICU.

The diagnosis and management of heparin-induced thrombocytopenia on ICU:

1. Recognise the clinical features and risk factors for heparin-induced thrombocytopenia (HIT) in critically ill patients.
2. Understand the diagnostic approach to HIT, including the use of immunoassays and functional assays.
3. Learn about the management strategies for HIT on the ICU, including the use of alternative anticoagulants and the role of plasma exchange in severe cases.

The management of TTP in critical care:

1. Understand the pathophysiology and clinical presentation of thrombotic thrombocytopenic purpura (TTP) in critically ill patients.
2. Learn about the diagnostic criteria and the role of ADAMTS13 testing in the diagnosis of TTP.
3. Discuss the management strategies for TTP in the critical care setting, including the use of plasma exchange, immunosuppressive therapy, and novel therapies such as caplacizumab.

• 10:00 Welcome and introduction - Andrew Retter, Chair
• 10:05 Management of sickle cell anaemia on ITU - Rachel Kesse-Adu
• 10:40 Management of red cell transfusions on ITU - Simon Stanworth
• 11:15 Management of platelet transfusions on ITU - Alexander Vlaar
• 11:45 Break
• 12:00 Management of tumour lysis syndrome - Mary Owen
• 12:20 Management of cytokine release syndrome and ICANs in patients admitted to critical care - Claire Roddy
• 12:55 Sum-up and break for Lunch
• 13:00 Lunch
• 14:00 Immunothrombosis and models of haemostasis and thrombosis - Andrew Retter
• 14:30 Monitoring anticoagulation in critical care - Teddy Hla and Fraser Hanks
• 14:50 Break
• 15:00 The diagnosis and management of heparin induced thrombocytopenia on ICU - Andrew Doyle
• 15:25 The management of TTP in critical care - Marie Scully
• 15:55 Close

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