Inside Intensive Care: Controversies Around Infection Management in Intensive Care

Dr Louis Kreitmann

Intensive Care Consultant and Clinical Academic , Guy’s and St Thomas’ NHS Foundation Trust and King’s College London

I am an intensive care consultant and clinical academic at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. My research focuses on the epidemiology, diagnosis and management of severe infections, with particular interests in immunocompromised patients and antimicrobial resistance.

I contribute to and lead multicentre observational studies of infections in ICU patients, and recently completed a PhD at Imperial College London investigating AI-based approaches to enhance multiplex PCR diagnostics in clinical microbiology.

Dr Chaz Langelier

Infectious Disease Physician Scientist , University of California San Francisco

Dr. Langelier is an infectious disease physician scientist in Department of Medicine at University of California San Francisco. His work seeks to advance the understanding and management of pneumonia, sepsis, and other infectious and inflammatory diseases through clinical investigation leveraging multi-omic technologies. In tandem, he works to reduce the burden of infectious diseases both in the United States and globally, through clinical practice and public health interventions. Research in the Langelier Lab encompasses three central areas: developing novel molecular diagnostic and prognostic tests, studying the host/pathogen biology of pneumonia and sepsis, and advancing methods for the surveillance of emerging infections. Together, by combining research, clinical practice, and mentoring, Dr. Langelier aims to advance the management and understanding of pneumonia, sepsis, and other critical infectious disease syndromes while uplifting the next generation of biomedical investigators.

Professor Manu Shankar Hari

Professor of Critical Care Medicine, King’s College London

Professor Manu Shankar-Hari is Professor of Critical Care Medicine and Director of the Centre for Critical Illness Research in the Faculty of Life Sciences & Medicine. He leads an internationally recognised, cross-disciplinary translational research programme spanning mechanistic discovery, clinical trials, and clinical practice-changing guidelines, focused on the global challenge of sepsis and sepsis survivorship. His work integrates immunobiology and clinical sciences to define critical illness phenotypes, advance drug repurposing and target discovery, and enable precision immunomodulation in critically ill patients, with a particular focus on critical illness due to infections (i.e., sepsis).

In recognition of his scientific leadership and contributions to medicine, he was elected a Fellow of the Royal Society of Edinburgh in 2025.

: @msh_manu