Toxicology and Drug Management in the ICU: Current Evidence and Clinical Impacts

9.15am – 10.30am BST, 3 July 2025 ‐ 1 hour 15 mins

Stream 2

This session explores critical aspects of drug safety in ICU, starting with the latest evidence on managing ingested poisons—from gastric decontamination to enhanced elimination techniques—with practical insights for complex toxicology cases. A military expert will then discuss clinical management of chemical and biological warfare agents, including Novichok and emerging threats. Next, we’ll examine national medicines shortage management, governance by DHSC and NHSE, and the global supply chain’s impact, using ICU and anaesthesia medicines as real-world examples. Finally, the session will address drug allergy labelling—focusing on penicillin allergy—and its effects on surgical and ICU outcomes. Emerging research on delabelling in critical care will be discussed, offering practical approaches to safer prescribing. Learning Objectives:

· Understand national systems for medicine shortage mitigation and their relevance to critical care

· Apply evidence-based toxicology principles to the management of poisoning in ICU

· Become familiar with presentation and management of chemical and biological weapons.

· Evaluate the risks of inaccurate allergy labels and opportunities for delabelling in critical care

 

Chairperson: Tom Billyard, Reena Mehta and David Sapsford

Jonathan Looms - Key updates in managing poisonings: methods to reduce absorption and enhance elimination of poisons.

Andy Johnstone - Managing Chemical and Biological agent poisoning in critical care - lessons from Salisbury

Louise Savic - Challenging Drug Allergy Labels: Relevance for ICU and Surgical Patients

Justine Scanlan - Out of Stock: Managing Medicines Shortages in Critical Care